Caryophyllene oxide Products | Cleanchem - Caryophyllene oxide is a sesquiterpene found in many essential oils, including black pepper, cloves, and cannabis. It is known for its anti-inflammatory, antimicrobial, and analgesic properties. Caryophyllene oxide is being studied for its potential in treating pain and inflammation, as well as its ability to interact with the body's endocannabinoid system. Side effects are rare, but it may cause skin irritation in sensitive individuals.