Colfosceril Products | Cleanchem - Colfosceril is a surfactant used in the treatment of respiratory distress syndrome (RDS) in neonates. It works by reducing surface tension in the lungs, helping the lungs expand more easily and improving oxygenation. Colfosceril is commonly administered to premature infants who have insufficient surfactant production. Side effects are generally rare but may include temporary low oxygen levels and lung inflammation.