Crinecerfont Products | Cleanchem - Crinecerfont is an investigational drug being studied for the treatment of conditions related to excess adrenal corticosteroid production, such as Cushing's disease. It is a selective CRF1 receptor antagonist, which helps to reduce the excessive release of cortisol, a hormone involved in stress and metabolism. By blocking the CRF1 receptor, Crinecerfont may help control symptoms like weight gain, high blood pressure, and fatigue associated with Cushing? disease. It is still under clinical investigation for its safety and efficacy.