Ceftolozane Products | Cleanchem - Ceftolozane, often combined with tazobactam, is a fifth-generation cephalosporin used to treat multidrug-resistant Gram-negative infections, including those caused by Pseudomonas aeruginosa. It is effective in complicated urinary tract and intra-abdominal infections. This combination enhances resistance to beta-lactamase-producing organisms. It is administered intravenously and reserved for serious hospital-acquired infections.