Chlorpropamide Products | Cleanchem - Chlorpropamide is an oral antidiabetic drug used to treat type 2 diabetes. It works by stimulating the pancreas to release more insulin and increasing the body's sensitivity to insulin. Chlorpropamide is part of the sulfonylurea class of medications and is usually prescribed when diet and exercise alone are insufficient to control blood sugar levels. Side effects can include weight gain, hypoglycemia, and allergic skin reactions.