Clothianidin Products | Cleanchem - Clothianidin is a neonicotinoid insecticide used to control a variety of pests, including fleas, mosquitoes, and agricultural insects. It works by targeting the nicotinic acetylcholine receptors in the nervous system of insects, leading to paralysis and death. Clothianidin is widely used in agricultural settings and pest control products. Although generally safe for humans, exposure can lead to mild skin irritation and potential environmental concerns regarding bee populations.