Carglumic Acid Products | Cleanchem - Carglumic acid is used to treat hyperammonemia in patients with N-acetylglutamate synthase (NAGS) deficiency, a rare genetic disorder affecting the urea cycle. It works by enhancing the activity of NAGS, which helps to convert ammonia to urea, thereby reducing ammonia buildup. Carglumic acid is part of the management of hyperammonemic episodes in affected individuals. Common side effects include nausea, vomiting, and abdominal pain.