Cefalotin Products | Cleanchem - Cefalotin (cephalothin) is a first-generation cephalosporin used primarily for treating bacterial infections such as pneumonia, urinary tract infections, and surgical prophylaxis. It is administered intravenously or intramuscularly. It disrupts bacterial cell wall formation, leading to cell death. Hypersensitivity reactions may occur, especially in penicillin-allergic patients.