Clotrimazole Products | Cleanchem - Clotrimazole is an antifungal medication used to treat a variety of fungal infections, including athlete? foot, ringworm, and vaginal yeast infections. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. Clotrimazole is available in topical, oral, and vaginal formulations. Side effects can include irritation or redness at the application site, as well as allergic reactions.