Ledipasvir Products | Cleanchem - Ledipasvir is a direct-acting antiviral agent used in combination with sofosbuvir for the treatment of chronic hepatitis C virus (HCV) infection, particularly genotype 1. It inhibits the HCV NS5A protein, which is essential for viral replication. The ledipasvir-sofosbuvir combination offers high cure rates and is generally well tolerated. Common side effects include fatigue and headache.