Lincomycin Hydrochloride Hydrate Products | Cleanchem - Lincomycin is a lincosamide antibiotic used to treat serious infections caused by Gram-positive bacteria, particularly in patients allergic to penicillin. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. It is administered orally, intramuscularly, or intravenously. Its use has declined due to the development of clindamycin, a related compound.