Lofexidine Products | Cleanchem - Lofexidine is an alpha-2 adrenergic agonist used to manage withdrawal symptoms in opioid-dependent individuals. It reduces norepinephrine release, thereby alleviating symptoms such as anxiety, sweating, and restlessness. Unlike clonidine, lofexidine has a lower risk of hypotension, making it more tolerable. It is approved for short-term use in detoxification settings.