Ponatinib Products | Cleanchem - Ponatinib is a tyrosine kinase inhibitor used to treat chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It works by blocking abnormal proteins caused by the Philadelphia chromosome, which contributes to cancer cell growth. Ponatinib is often used when other treatments have failed or when the cancer is resistant to other therapies.