Voxelotor Products | Cleanchem - Voxelotor is a hemoglobin modulator approved for the treatment of sickle cell disease. It works by increasing hemoglobin's affinity for oxygen, which helps inhibit the polymerization of sickled hemoglobin and thereby reduces hemolysis and anemia. Voxelotor improves hemoglobin levels and reduces markers of hemolytic activity. It represents a disease-modifying treatment that targets the root cause of sickling in red blood cells.