Xylometazoline Products | Cleanchem - Xylometazoline is a topical decongestant used in the treatment of nasal congestion associated with conditions like the common cold, sinusitis, or allergic rhinitis. It works by constricting the blood vessels in the nasal passages, reducing swelling and allowing easier breathing. Xylometazoline is typically used in nasal sprays or drops and should not be used for more than a few days to avoid rebound congestion.