Zolpidem Products | Cleanchem - Zolpidem is a sedative-hypnotic used in the short-term treatment of insomnia. It works by enhancing the activity of GABA, a neurotransmitter that promotes sleep. Zolpidem helps people fall asleep quickly and stay asleep longer, but it is typically prescribed for short durations due to its potential for dependence. It is often used when other sleep aids are ineffective.