Impurity Reference Standard - Products

Irinotecan HCl Trihydrate

CAT No: CL-ICN-01 CAS No: 136572-09-3 Mol Wt: 586.7 : 36.5 : 3(18.0) Mol F: C33H38N4O6 : HCl : 3(H2O) Inv Status: Custom Synthesis

Chemical Name: (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate

Irinotecan EP Impurity B

CAT No: CL-ICN-02 CAS No: 19685-09-7 Mol Wt: 364.4 Mol F: C20H16N2O5 Inv Status: Custom Synthesis

Chemical Name: (4S)-4-ethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (as per USP)

Irinotecan EP Impurity E

CAT No: CL-ICN-03 CAS No: 86639-52-3 Mol Wt: 392.4 Mol F: C22H20N2O5 Inv Status: Custom Synthesis

Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ; (S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (as per USP)

Irinotecan

CAT No: CL-ICN-05 CAS No: NA Mol Wt: 586.7 : 36.5 : 3(18.0) Mol F: C33H38N4O6 : HCl : 3(H2O) Inv Status: Custom Synthesis

Chemical Name: (R)-9-[(1,4'-Bipiperidine)-1'-carbonyloxy]-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline hydrochloride, trihydrate (as per USP)

Irinotecan EP Impurity F

CAT No: CL-ICN-06 CAS No: 78287-27-1 Mol Wt: 376.4 Mol F: C22H20N2O4 Inv Status: Custom Synthesis

Chemical Name: (S)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione ; (S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione (as per USP)

Irinotecan EP Impurity G

CAT No: CL-ICN-07 CAS No: 947687-01-6 Mol Wt: 420.5 Mol F: C24H24N2O5 Inv Status: Custom Synthesis

Chemical Name: (4S)-4,8,11-triethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione ; (S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (as per USP)

Irinotecan EP Impurity M

CAT No: CL-ICN-08 CAS No: 185336-12-3 Mol Wt: 602.7 Mol F: C33H38N4O7 Inv Status: Custom Synthesis

Chemical Name: (4S)-4,11-diethyl-4,12-dihydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl 1,4?-bipiperidine-1?-carboxylate

Irinotecan Keto Impurity

CAT No: CL-ICN-10 CAS No: 176515-52-9 Mol Wt: 542.7 Mol F: C32H38N4O4 Inv Status: Custom Synthesis

Chemical Name: 12-Ethyl-8-methyl-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan Hydroxy Keto Impurity

CAT No: CL-ICN-11 CAS No: 157770-58-6 Mol Wt: 348.4 Mol F: C21H20N2O3 Inv Status: Custom Synthesis

Chemical Name: 12-Ethyl-2-hydroxy-8-methyl-7-propionylindolizino[1,2-b]quinolin-9(11H)-one

Irinotecan EP Impurity A

CAT No: CL-ICN-12 CAS No: 158406-44-1 Mol Wt: 558.6 : 36.5 : 3(18.0) Mol F: C31H34N4O6 : HCl : 3(H2O) Inv Status: Custom Synthesis

Chemical Name: (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl 1,4?-bipiperidine-1?-carboxylate hydrochloride trihydrate ;(S)-4-Ethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione-9-yl (1,4?-bipiperidine)-1?-carboxylate hydrochloride trihydrate (as per USP)

Irinotecan Impurity 1

CAT No: CL-ICN-14 CAS No: 143490-53-3 Mol Wt: 556.7 Mol F: C32H36N4O5 Inv Status: Custom Synthesis

Chemical Name: 3,10-Diethyl-1,13-dioxo-11,13-dihydro-1H,3H-furo[3',4':6,7]indolizino[1,2-b]quinolin-8-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan Impurity 2

CAT No: CL-ICN-15 CAS No: NA Mol Wt: 558.7 Mol F: C32H38N4O5 Inv Status: Custom Synthesis

Chemical Name: 3,10-Diethyl-3-hydroxy-13-oxo-11,13-dihydro-1H,3H-furo[3',4':6,7]indolizino[1,2-b]quinolin-8-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan Impurity 4

CAT No: CL-ICN-17 CAS No: 121080-63-5 Mol Wt: 568.5 Mol F: C28H28N2O11 Inv Status: Custom Synthesis

Chemical Name: 6-(((S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Irinotecan Impurity 5

CAT No: CL-ICN-18 CAS No: 2656-50-0 Mol Wt: 151.2 : 18.0 Mol F: C8H9NO2 : HCl Inv Status: Custom Synthesis

Chemical Name: 1-(2-Amino-5-hydroxyphenyl)ethan-1-one hydrochloride

Irinotecan EP Impurity C

CAT No: CL-ICN-19 CAS No: 947687-02-7 Mol Wt: 614.7 Mol F: C35H42N4O6 Inv Status: Custom Synthesis

Chemical Name: (S)-4,8,11-Triethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan EP Impurity D

CAT No: CL-ICN-20 CAS No: [7689-03-4] Mol Wt: 348.4 Mol F: C20H16N2O4 Inv Status: Custom Synthesis

Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione

Irinotecan EP Impurity L

CAT No: CL-ICN-21 CAS No: NA Mol Wt: 586.7 : 114.0 Mol F: C33H38N4O6 : C2HF3O2 Inv Status: Custom Synthesis

Chemical Name: (4R)-4,11-Diethyl-4-Hydroxy-3,14-Dioxo-3,4,12,14-Tetrahydro-1H-Pyrano[3?,4?:6,7]Indolizino[1,2-B]Quinolin-9-Yl 1,4?-Bipiperidine-1?-Carboxylate 2,2,2-trifluoroacetate (As Per EP) ; (R)-9-[(1,4'-Bipiperidine)-1'-Carbonyloxy]-4,11-Diethyl-3,4,12,14-Tetrahydro-4-Hydroxy-3,14-Dioxo-1H-Pyrano[3',4':6,7]Indolizino[1,2-B]Quinoline 2,2,2-trifluoroacetate

Irinotecan Acid (Sodium salt)

CAT No: CL-ICN-22 CAS No: 1329502-92-2 Mol Wt: 603.7 : 23.0 Mol F: C33H39N4O7 : Na Inv Status: Custom Synthesis

Chemical Name: Sodium (S)-2-(2-(([1,4'-bipiperidine]-1'-carbonyl)oxy)-12-ethyl-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate

Irinotecan EP Impurity G TFA

CAT No: CL-ICN-23 CAS No: NA Mol Wt: 420.5 : 114.0 Mol F: C24H24N2O5 : C2HF3O2 Inv Status: Custom Synthesis

Chemical Name: (4S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Trifluoroacetate(as per EP); (S)-4,8,11-Triethyl-4,9-dihydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Trifluoroacetate

Irinotecan EP Impurity C TFA

CAT No: CL-ICN-24 CAS No: NA Mol Wt: 614.7 : 114.0 Mol F: C35H42N4O6 : C2HF3O2 Inv Status: Custom Synthesis

Chemical Name: (S)-4,8,11-Triethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quin oline-3,14(4H,12H)-dione-9-yl (1,4?-bipiperidine)-1?-carboxylate Trifluoroacetate

Irinotecan EP Impurity M (HCl salt)

CAT No: CL-ICN-25 CAS No: NA Mol Wt: 602.7 : 36.5 Mol F: C33H38N4O7 : HCl Inv Status: Custom Synthesis

Chemical Name: (4S)-4,11-diethyl-4,12-dihydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl 1,4?-bipiperidine-1?-carboxylate hydrochloride

Irinotecan EP Impurity H

CAT No: CL-ICN-26 CAS No: 1608617-71-5 Mol Wt: 572.7 Mol F: C32H36N4O6 Inv Status: Custom Synthesis

Chemical Name: (4S)-11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl 1,4?-bipiperidine-1?-carboxylate

Irinotecan EP Impurity K

CAT No: CL-ICN-27 CAS No: 2508174-07-8 Mol Wt: 616.7 Mol F: C34H40N4O7 Inv Status: Custom Synthesis

Chemical Name: (4S)-4-Ethyl-4-hydroxy-11-(1-hydroxypropyl)-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl 1,4?-bipiperidine-1?-carboxylate

Irinotecan Impurity 10

CAT No: CL-ICN-28 CAS No: NA Mol Wt: 542.6 Mol F: C31H34N4O5 Inv Status: Custom Synthesis

Chemical Name: 11-Ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan Impurity 6

CAT No: CL-ICN-29 CAS No: 200619-21-2 Mol Wt: 408.4 Mol F: C22H20N2O6 Inv Status: Custom Synthesis

Chemical Name: (4S)-4,11-Diethyl-4,9,12-trihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione

Irinotecan Impurity 7

CAT No: CL-ICN-30 CAS No: NA Mol Wt: 260.8 Mol F: C12H21ClN2O2 Inv Status: Custom Synthesis

Chemical Name: 2'-Methoxy-[1,4'-bipiperidine]-1'-carbonyl chloride

Irinotecan Impurity 8

CAT No: CL-ICN-31 CAS No: NA Mol Wt: 274.8 Mol F: C13H23ClN2O2 Inv Status: Custom Synthesis

Chemical Name: 2'-Ethoxy-[1,4'-bipiperidine]-1'-carbonyl chloride

Irinotecan Impurity 9

CAT No: CL-ICN-32 CAS No: 185304-41-0 Mol Wt: 560.7 Mol F: C32H40N4O5 Inv Status: Custom Synthesis

Chemical Name: (S)-12-ethyl-8-(hydroxymethyl)-7-(1-hydroxypropyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4'-bipiperidine]-1'-carboxylate

Irinotecan Impurity B1

CAT No: CL-ICN-33 CAS No: NA Mol Wt: 246.7 Mol F: C11H19ClN2O2 Inv Status: Custom Synthesis

Chemical Name: 2'-Hydroxy-[1,4'-bipiperidine]-1'-carbonyl chloride

Irinotecan Impurity D

CAT No: CL-ICN-34 CAS No: NA Mol Wt: 630.7 Mol F: C35H42N4O7 Inv Status: Custom Synthesis

Chemical Name: (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 2'-ethoxy-[1,4'-bipiperidine]-1'-carboxylate

Irinotecan Acid

CAT No: CL-ICN-35 CAS No: 142706-06-7 Mol Wt: 604.7 Mol F: C33H40N4O7 Inv Status: Custom Synthesis

Chemical Name: (S)-2-(2-(([1,4'-bipiperidine]-1'-carbonyl)oxy)-12-ethyl-8-(hydroxymethyl)-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoic acid

Irinotecan USP Related Compound C

CAT No: CL-ICN-36 CAS No: NA Mol Wt: 572.7 : 36.5 Mol F: C32H36N4O6 : HCl Inv Status: Custom Synthesis

Chemical Name: 11-Ethyl-4-hydroxy-4-methyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinolin-9-yl (1,4?-bipiperidine)-1?-carboxylate hydrochloride

SN-38 Carboxylate Disodium Salt

CAT No: CL-ICN-37 CAS No: NA Mol Wt: 408.4 : 2(23.0) Mol F: C22H20N2O6 : 2(Na) Inv Status: Custom Synthesis

Chemical Name: Sodium (S)-2-(12-ethyl-8-(hydroxymethyl)-2-oxido-9-oxo-9,11-dihydroindolizino[1,2-b]quinolin-7-yl)-2-hydroxybutanoate

Irinotecan Impurity 11

CAT No: CL-ICN-38 CAS No: 103816-19-9 Mol Wt: 230.7 Mol F: C11H19ClN2O Inv Status: Custom Synthesis

Chemical Name: [1,4'-Bipiperidine]-1'-carbonyl chloride

Racemic Irinotecan

CAT No: CL-ICN-39 CAS No: 130144-33-1 Mol Wt: 586.7 Mol F: C33H38N4O6 Inv Status: Custom Synthesis

Chemical Name: 4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate

Type:Impurity Reference Standard

API NAME:Irinotecan

Total Products: 35

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