Impurity Reference Standard - Products

Ivosidenib

CAT No: CL-IVDN-01 CAS No: 1448347-49-6 Mol Wt: 583 Mol F: C28H22ClF3N6O3 Inv Status: Custom Synthesis

Chemical Name: (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 1

CAT No: CL-IVDN-02 CAS No: NA Mol Wt: 141.5 Mol F: C4H6ClF2N Inv Status: Custom Synthesis

Chemical Name: 2-Chloro-3,3-difluorocyclobutan-1-amine

Ivosidenib Impurity 2

CAT No: CL-IVDN-03 CAS No: NA Mol Wt: 703.1 Mol F: C34H26ClF3N8O4 Inv Status: Custom Synthesis

Chemical Name: (S)-4-(Bis(4-cyanopyridin-2-yl)amino)-5-(((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)(5-fluoropyridin-3-yl)amino)-5-oxopentanoic acid

Ivosidenib Impurity 3

CAT No: CL-IVDN-04 CAS No: NA Mol Wt: 391.8 Mol F: C18H15ClFN3O4 Inv Status: Custom Synthesis

Chemical Name: (2R)-2-(2-Chlorophenyl)-2-(N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamido)acetic acid

Ivosidenib Impurity 4

CAT No: CL-IVDN-05 CAS No: NA Mol Wt: 493.9 Mol F: C24H17ClFN5O4 Inv Status: Custom Synthesis

Chemical Name: (R)-2-(2-Chlorophenyl)-2-((S)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamido)acetic acid

Ivosidenib Impurity 5

CAT No: CL-IVDN-06 CAS No: NA Mol Wt: 599 Mol F: C28H22ClF3N6O4 Inv Status: Custom Synthesis

Chemical Name: (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyano-1-(l1-oxidanyl)-1l4-pyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 6

CAT No: CL-IVDN-07 CAS No: NA Mol Wt: 599 Mol F: C28H22ClF3N6O4 Inv Status: Custom Synthesis

Chemical Name: (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoro-1-(l1-oxidanyl)-1l4-pyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 7

CAT No: CL-IVDN-08 CAS No: NA Mol Wt: 615 Mol F: C28H22ClF3N6O5 Inv Status: Custom Synthesis

Chemical Name: (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyano-1-(l1-oxidanyl)-1l4-pyridin-2-yl)-N-(5-fluoro-1-(l1-oxidanyl)-1l4-pyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 8

CAT No: CL-IVDN-09 CAS No: 2408269-74-7 Mol Wt: 617 Mol F: C28H24ClF3N6O5 Inv Status: Custom Synthesis

Chemical Name: 3-((S)-1-(4-Carbamoylpyridin-2-yl)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-5-oxopyrrolidine-2-carboxamido)-5-fluoropyridine 1-oxide

Ivosidenib Impurity 9

CAT No: CL-IVDN-10 CAS No: NA Mol Wt: 617 Mol F: C28H24ClF3N6O5 Inv Status: Custom Synthesis

Chemical Name: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Isonicotinamide

CAT No: CL-IVDN-11 CAS No: 2408269-64-5 Mol Wt: 601 Mol F: C28H24ClF3N6O4 Inv Status: Custom Synthesis

Chemical Name: 2-((S)-2-(((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)(5-fluoropyridin-3-yl)carbamoyl)-5-oxopyrrolidin-1-yl)isonicotinamide

(R,R)-Ivosidenib

CAT No: CL-IVDN-12 CAS No: 2408269-66-7 Mol Wt: 583 Mol F: C28H22ClF3N6O3 Inv Status: Custom Synthesis

Chemical Name: (R)-N-((R)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

(S,R)-Ivosidenib

CAT No: CL-IVDN-13 CAS No: 2070009-31-1 Mol Wt: 583 Mol F: C28H22ClF3N6O3 Inv Status: Custom Synthesis

Chemical Name: (S)-N-((R)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Ethyl Ester Impurity

CAT No: CL-IVDN-14 CAS No: 2602249-21-6 Mol Wt: 630 Mol F: C30H27ClF3N5O5 Inv Status: Custom Synthesis

Chemical Name: Ethyl 2-((S)-2-(((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)(5-fluoropyridin-3-yl)carbamoyl)-5-oxopyrrolidin-1-yl)isonicotinate

Ivosidenib Impurity 10

CAT No: CL-IVDN-15 CAS No: 1448346-63-1 Mol Wt: 583 Mol F: C28H22ClF3N6O3 Inv Status: Custom Synthesis

Chemical Name: (2S)-N-(1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 11

CAT No: CL-IVDN-16 CAS No: 2640820-07-9 Mol Wt: 325.3 Mol F: C16H12FN5O2 Inv Status: Custom Synthesis

Chemical Name: (S)-1-(4-Cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide

Ivosidenib Impurity 12

CAT No: CL-IVDN-17 CAS No: 2752477-52-2 Mol Wt: 321.3 Mol F: C18H15N3O3 Inv Status: Custom Synthesis

Chemical Name: Benzyl (S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylate

Ivosidenib Impurity 13

CAT No: CL-IVDN-18 CAS No: 2640820-09-1 Mol Wt: 259.3 Mol F: C13H13N3O3 Inv Status: Custom Synthesis

Chemical Name: Ethyl (S)-1-(4-cyanopyridin-2-yl)-5-oxopyrrolidine-2-carboxylate

Ivosidenib N-Oxide Impurity 1

CAT No: CL-IVDN-20 CAS No: 2408269-74-7 Mol Wt: 617 Mol F: C28H24ClF3N6O5 Inv Status: Custom Synthesis

Chemical Name: 3-((S)-1-(4-Carbamoylpyridin-2-yl)-N-((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-5-oxopyrrolidine-2-carboxamido)-5-fluoropyridine 1-oxide

Ivosidenib N-Oxide Impurity 2

CAT No: CL-IVDN-21 CAS No: NA Mol Wt: 617 Mol F: C28H24ClF3N6O5 Inv Status: Custom Synthesis

Chemical Name: 4-Carbamoyl-2-((S)-2-(((S)-1-(2-chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)(5-fluoropyridin-3-yl)carbamoyl)-5-oxopyrrolidin-1-yl)pyridine 1-oxide

Ivosidenib Impurity 14

CAT No: CL-IVDN-22 CAS No: 791061-00-2 Mol Wt: 107.1 Mol F: C4H7F2N Inv Status: Custom Synthesis

Chemical Name: 3,3-Difluorocyclobutan-1-amine

Ivosidenib Impurity 15

CAT No: CL-IVDN-23 CAS No: 637031-93-7 Mol Wt: 107.1 : 36.5 Mol F: C4H7F2N : HCl Inv Status: Custom Synthesis

Chemical Name: 3,3-Difluorocyclobutan-1-amine hydrochloride

Type:Impurity Reference Standard

API NAME:Ivosidenib

Total Products: 22

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