Impurity Reference Standard - Products

Nilotinib

CAT No: CL-NLT-01 CAS No: 641571-10-0 Mol Wt: 529.5 Mol F: C28H22F3N7O Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib EP Impurity A

CAT No: CL-NLT-02 CAS No: 641571-11-1 Mol Wt: 241.2 Mol F: C11H10F3N3 Inv Status: In Stock

Chemical Name: 3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 19

CAT No: CL-NLT-03 CAS No: 17071-24-8 Mol Wt: 149.2 Mol F: C9H11NO Inv Status: Custom Synthesis

Chemical Name: 1-(3-Amino-4-methylphenyl)ethan-1-one

Nilotinib EP Impurity C

CAT No: CL-NLT-04 CAS No: 2458-12-0 Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 3-Amino-4-methylbenzoic acid

Nilotinib EP Impurity D

CAT No: CL-NLT-05 CAS No: 641569-94-0 Mol Wt: 306.3 Mol F: C17H14N4O2 Inv Status: In Stock

Chemical Name: 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid

Nilotinib EP Impurity E

CAT No: CL-NLT-06 CAS No: 2119583-26-3 Mol Wt: 515.5 Mol F: C27H20F3N7O Inv Status: Custom Synthesis

Chemical Name: N-(3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib EP Impurity F

CAT No: CL-NLT-07 CAS No: 2119583-24-1 Mol Wt: 543.6 Mol F: C29H24F3N7O Inv Status: Custom Synthesis

Chemical Name: N-(3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib EP Impurity G

CAT No: CL-NLT-08 CAS No: 917392-54-2 Mol Wt: 320.6 Mol F: C18H16N4O2 Inv Status: Custom Synthesis

Chemical Name: Methyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate

Nilotinib EP Impurity H

CAT No: CL-NLT-09 CAS No: 641571-15-5 Mol Wt: 529.5 Mol F: C28H22F3N7O Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-N-(3-(5-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Iodo Impurity

CAT No: CL-NLT-10 CAS No: 926922-18-1 Mol Wt: 485.3 Mol F: C19H15F3IN3O Inv Status: Custom Synthesis

Chemical Name: 3-Iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Nilotinib 2-Pyridinyl Impurity

CAT No: CL-NLT-11 CAS No: 66521-65-1 Mol Wt: 172.2 Mol F: C9H8N4 Inv Status: Custom Synthesis

Chemical Name: 4-(Pyridin-2-yl)pyrimidin-2-amine

Nilotinib 3-Pyridinyl Impurity

CAT No: CL-NLT-12 CAS No: 66521-66-2 Mol Wt: 172.2 Mol F: C9H8N4 Inv Status: Custom Synthesis

Chemical Name: 4-(Pyridin-2-yl)pyrimidin-2-amine

Nilotinib Bromo Impurity

CAT No: CL-NLT-13 CAS No: 54962-75-3 Mol Wt: 240 Mol F: C7H5BrF3N Inv Status: Custom Synthesis

Chemical Name: 3-Bromo-5-(trifluoromethyl)aniline

Nilotinib N-Oxide

CAT No: CL-NLT-14 CAS No: 1246817-85-5 Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 3-(2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)pyrimidin-4-yl)pyridine 1-oxide

Nilotinib Impurity 1

CAT No: CL-NLT-15 CAS No: 641571-06-4 Mol Wt: 241.2 Mol F: C11H10F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(2-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 2

CAT No: CL-NLT-16 CAS No: 943320-48-7 Mol Wt: 227.2 Mol F: C10H8F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 3

CAT No: CL-NLT-17 CAS No: 2119583-28-5 Mol Wt: 255.24 Mol F: C12H12F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(2,4-Dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 4

CAT No: CL-NLT-18 CAS No: 641571-16-6 Mol Wt: 241.2 Mol F: C11H10F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 5

CAT No: CL-NLT-19 CAS No: 641571-05-3 Mol Wt: 529.5 Mol F: C28H22F3N7O Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-N-(3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 6

CAT No: CL-NLT-20 CAS No: 2468737-73-5 Mol Wt: 362.4 Mol F: C21H22N4O2 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate

Nilotinib Impurity 7

CAT No: CL-NLT-21 CAS No: 2119583-25-2 Mol Wt: 543.6 Mol F: C29H24F3N7O Inv Status: Custom Synthesis

Chemical Name: N-(3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 8

CAT No: CL-NLT-22 CAS No: 641571-12-2 Mol Wt: 251.2 Mol F: C12H8F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile

Nilotinib Impurity 9

CAT No: CL-NLT-23 CAS No: 917391-28-7 Mol Wt: 269.2 Mol F: C12H10F3N3O Inv Status: Custom Synthesis

Chemical Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide

Nilotinib Impurity 10

CAT No: CL-NLT-24 CAS No: 641571-13-3 Mol Wt: 270.2 Mol F: C12H9F3N2O2 Inv Status: Custom Synthesis

Chemical Name: 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid

Nilotinib Impurity 11

CAT No: CL-NLT-25 CAS No: 916975-92-3 Mol Wt: 271.2 Mol F: C11H8F3N3O2 Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-1-(3-nitro-5-(trifluoromethyl)phenyl)-1H-imidazole

Nilotinib Impurity 12

CAT No: CL-NLT-26 CAS No: 123367-26-0 Mol Wt: 176.2 Mol F: C10H12N2O Inv Status: Custom Synthesis

Chemical Name: (E)-3-(Dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

Nilotinib Impurity 13

CAT No: CL-NLT-27 CAS No: NA Mol Wt: 255.2 : 36.5 Mol F: C12H12F3N3 : HCl Inv Status: Custom Synthesis

Chemical Name: 3-(4-ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline hydrochloride

Nilotinib Impurity 14

CAT No: CL-NLT-28 CAS No: 851137-91-2 Mol Wt: 305.3 Mol F: C17H15N5O Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 15

CAT No: CL-NLT-29 CAS No: 2468737-74-6 Mol Wt: 304.4 Mol F: C18H16N4O Inv Status: Custom Synthesis

Chemical Name: 1-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)ethan-1-one

Nilotinib Impurity 16

CAT No: CL-NLT-30 CAS No: 630125-49-4 Mol Wt: 270 Mol F: C7H3BrF3NO2 Inv Status: Custom Synthesis

Chemical Name: 1-Bromo-3-nitro-5-(trifluoromethyl)benzene

Nilotinib Impurity 17

CAT No: CL-NLT-31 CAS No: 98-46-4 Mol Wt: 191.1 Mol F: C7H4F3NO2 Inv Status: In Stock

Chemical Name: 1-Nitro-3-(trifluoromethyl)benzene

Nilotinib Impurity 18

CAT No: CL-NLT-32 CAS No: 2469039-94-7 Mol Wt: 564 Mol F: C28H21ClF3N7O Inv Status: Custom Synthesis

Chemical Name: 3-(5-Chloro-4-(pyridin-3-yl)pyrimidin-2-ylamino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Nilotinib EP Impurity B

CAT No: CL-NLT-33 CAS No: 18595-18-1 Mol Wt: 165.2 Mol F: C9H11NO2 Inv Status: Custom Synthesis

Chemical Name: Methyl 3-amino-4-methylbenzoate

Nilotinib 3-Imidazolyl N-oxide

CAT No: CL-NLT-34 CAS No: 2139382-75-3 Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-3-(4-pyridin-3-yl)pyrimidin-2-yl]amino-N-(5-(3-oxo-4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamine

Nilotinib Di N-Oxide

CAT No: CL-NLT-35 CAS No: NA Mol Wt: 561.5 Mol F: C28H22F3N7O3 Inv Status: Custom Synthesis

Chemical Name: 2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)-4-(1-oxidopyridin-3-yl)pyrimidine 1-oxide

Nilotinib Mono-N-oxide

CAT No: CL-NLT-36 CAS No: NA Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-1-(3-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamido)-5-(trifluoromethyl)phenyl)-1H-imidazole 1-oxide

Nilotinib N-Oxide (Pyrimidine N1-Oxide)

CAT No: CL-NLT-37 CAS No: NA Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)-4-(pyridin-3-yl)pyrimidine 1-oxide

Nilotinib N-Oxide (Pyrimidine N3-Oxide)

CAT No: CL-NLT-38 CAS No: NA Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 2-((2-Methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)amino)-4-(pyridin-3-yl)pyrimidine 1-oxide

Nilotinib Impurity 20

CAT No: CL-NLT-39 CAS No: 1157857-29-8 Mol Wt: 404.3 Mol F: C19H15F3N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-Methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-nitrobenzamide

Nilotinib Impurity 21

CAT No: CL-NLT-40 CAS No: NA Mol Wt: 564 Mol F: C28H21ClF3N7O Inv Status: Custom Synthesis

Chemical Name: 3-((4-Chloro-6-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Nilotinib Impurity 22

CAT No: CL-NLT-41 CAS No: NA Mol Wt: 661.6 Mol F: C32H26F3N7O6 Inv Status: Custom Synthesis

Chemical Name: 2,3-Dihydroxy-4-((2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)(4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-oxobutanoic acid

Nilotinib Impurity 23

CAT No: CL-NLT-42 CAS No: NA Mol Wt: 644.6 Mol F: C32H25F3N7O5 Inv Status: Custom Synthesis

Chemical Name: 3,4-Dihydroxy-1-(2-methyl-5-((3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamoyl)phenyl)-2,5-dioxo-1-(4-(pyridin-3-yl)pyrimidin-2-yl)pyrrolidin-1-ium

Nilotinib Impurity 24

CAT No: CL-NLT-43 CAS No: NA Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: N-(3-(4-(Hydroxymethyl)-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 25

CAT No: CL-NLT-44 CAS No: 1807607-72-2 Mol Wt: 559.5 Mol F: C28H20F3N7O3 Inv Status: Custom Synthesis

Chemical Name: 1-(3-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamido)-5-(trifluoromethyl)phenyl)-1H-imidazole-4-carboxylic acid

Nilotinib Impurity 26

CAT No: CL-NLT-45 CAS No: 1807608-52-1 Mol Wt: 545.5 Mol F: C28H22F3N7O2 Inv Status: Custom Synthesis

Chemical Name: 4-(Hydroxymethyl)-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 27

CAT No: CL-NLT-46 CAS No: 2119583-27-4 Mol Wt: 255.2 Mol F: C12H12F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(4-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 28

CAT No: CL-NLT-47 CAS No: NA Mol Wt: 255.2 Mol F: C12H12F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(5-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 29

CAT No: CL-NLT-48 CAS No: 41191-92-8 Mol Wt: 179.2 Mol F: C10H13NO2 Inv Status: Custom Synthesis

Chemical Name: Ethyl 3-amino-4-methylbenzoate

Nilotinib Impurity 30

CAT No: CL-NLT-49 CAS No: 66521-53-7 Mol Wt: 176.2 Mol F: C10H12N2O Inv Status: Custom Synthesis

Chemical Name: (E)-3-(Dimethylamino)-1-(pyridin-4-yl)prop-2-en-1-one

Nilotinib Impurity 31

CAT No: CL-NLT-50 CAS No: 1025716-99-7 Mol Wt: 207.2 : 63.0 Mol F: C10H13N3O2 : HNO3 Inv Status: Custom Synthesis

Chemical Name: Methyl 3-guanidino-4-methylbenzoate nitrate

Nilotinib Impurity 32

CAT No: CL-NLT-51 CAS No: NA Mol Wt: 241.2 Mol F: C11H10F3N3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Methyl-1H-imidazol-1-yl)-2-(trifluoromethyl)aniline

Nilotinib Impurity 33

CAT No: CL-NLT-52 CAS No: NA Mol Wt: 241.2 Mol F: C11H10F3N3 Inv Status: Custom Synthesis

Chemical Name: 2-(4-Methyl-1H-imidazol-1-yl)-6-(trifluoromethyl)aniline

Nilotinib Impurity 34

CAT No: CL-NLT-53 CAS No: 66521-54-8 Mol Wt: 176.2 Mol F: C10H12N2O Inv Status: Custom Synthesis

Chemical Name: 3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

Nilotinib Impurity 35

CAT No: CL-NLT-54 CAS No: 641569-96-2 Mol Wt: 221.3 : 63.0 Mol F: C11H15N3O2 : HNO3 Inv Status: Custom Synthesis

Chemical Name: Ethyl 3-guanidino-4-methylbenzoate nitrate

Nilotinib Impurity 36

CAT No: CL-NLT-55 CAS No: NA Mol Wt: 411.5 Mol F: C23H29N3O4 Inv Status: Custom Synthesis

Chemical Name: Butyl 3-(3-(5-(ethoxycarbonyl)-2-methylphenyl)guanidino)-4-methylbenzoate

Nilotinib Impurity 37

CAT No: CL-NLT-56 CAS No: 2021249-11-4 Mol Wt: 508.4 Mol F: C23H18F6N6O Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea

Nilotinib Impurity 38

CAT No: CL-NLT-57 CAS No: 915711-42-1 Mol Wt: 374.4 Mol F: C19H17F3N4O Inv Status: Custom Synthesis

Chemical Name: 3-Amino-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide

Nilotinib Impurity 39

CAT No: CL-NLT-58 CAS No: 149793-69-1 Mol Wt: 189.1 Mol F: C8H3F4N Inv Status: Custom Synthesis

Chemical Name: 3-Fluoro-5-(trifluoromethyl)benzonitrile

Nilotinib Impurity 40

CAT No: CL-NLT-59 CAS No: 123367-25-9 Mol Wt: 176.2 Mol F: C10H12N2O Inv Status: Custom Synthesis

Chemical Name: (E)-3-(Dimethylamino)-1-(pyridin-2-yl)prop-2-en-1-one

Nilotinib Impurity 41

CAT No: CL-NLT-60 CAS No: 641571-14-4 Mol Wt: 341.3 Mol F: C16H18F3N3O2 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl (3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)carbamate

Nilotinib Impurity 42

CAT No: CL-NLT-61 CAS No: 859026-97-4 Mol Wt: 193.2 Mol F: C9H11N3O2 Inv Status: Custom Synthesis

Chemical Name: 3-Guanidino-4-methylbenzoic acid

Nilotinib Impurity 43

CAT No: CL-NLT-62 CAS No: 641569-97-3 Mol Wt: 334.4 Mol F: C19H18N4O2 Inv Status: Custom Synthesis

Chemical Name: Ethyl 4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoate

Nilotinib Impurity 44

CAT No: CL-NLT-63 CAS No: 1260802-16-1 Mol Wt: 255.2 Mol F: C12H12F3N3 Inv Status: Custom Synthesis

Chemical Name: 3-(2-Ethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

Nilotinib Impurity 45

CAT No: CL-NLT-64 CAS No: NA Mol Wt: 263.3 Mol F: C12H17N5O2 Inv Status: Custom Synthesis

Chemical Name: Ethyl 3-(3-(diaminomethylene)guanidino)-4-methylbenzoate

Nilotinib Impurity 46

CAT No: CL-NLT-65 CAS No: [2840-04-2] Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 5-Amino-2-methylbenzoic acid

Nilotinib Impurity 47

CAT No: CL-NLT-66 CAS No: 2305-37-5 Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 3-Amino-5-methylbenzoic acid

Nilotinib Impurity 48

CAT No: CL-NLT-67 CAS No: 52130-17-3 Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 3-Amino-2-methylbenzoic acid

Nilotinib Impurity 49

CAT No: CL-NLT-68 CAS No: 2486-70-6 Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 4-Amino-3-methylbenzoic acid

Nilotinib Impurity 50

CAT No: CL-NLT-69 CAS No: 4389-45-1 Mol Wt: 151.2 Mol F: C8H9NO2 Inv Status: Custom Synthesis

Chemical Name: 2-Amino-3-methylbenzoic acid

Nilotinib Impurity 51

CAT No: CL-NLT-70 CAS No: NA Mol Wt: 411.5 Mol F: C21H25N5O4 Inv Status: Custom Synthesis

Chemical Name: Ethyl (E)-2-((5-(ethoxycarbonyl)-2-methylphenyl)diazenyl)-5-guanidino-4-methylbenzoate

Nilotinib Impurity 52

CAT No: CL-NLT-71 CAS No: 207986-20-7 Mol Wt: 207.1 Mol F: C8H5F4NO Inv Status: Custom Synthesis

Chemical Name: 3-Fluoro-5-(trifluoromethyl)benzamide

Nilotinib Impurity 53

CAT No: CL-NLT-72 CAS No: 641571-18-8 Mol Wt: 270.2 Mol F: C12H9F3N2O2 Inv Status: Custom Synthesis

Chemical Name: 3-(5-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid

Nilotinib Impurity 54

CAT No: CL-NLT-73 CAS No: NA Mol Wt: 434.4 Mol F: C19H20F6N4O Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(3-(dimethylamino)-5-(trifluoromethyl)phenyl)urea

Nilotinib Impurity 55

CAT No: CL-NLT-74 CAS No: 157383-41-0 Mol Wt: 233.2 Mol F: C10H10F3NO2 Inv Status: Custom Synthesis

Chemical Name: 3-(Dimethylamino)-5-(trifluoromethyl)benzoic acid

Nilotinib Impurity 56

CAT No: CL-NLT-75 CAS No: NA Mol Wt: 333.4 Mol F: C19H19N5O Inv Status: Custom Synthesis

Chemical Name: N,N,4-Trimethyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide

Nilotinib Impurity 57

CAT No: CL-NLT-76 CAS No: NA Mol Wt: 367.4 Mol F: C18H21N7O2 Inv Status: Custom Synthesis

Chemical Name: N-(N-(5-Carbamoyl-2-methylphenyl)carbamimidoyl)-3-guanidino-4-methylbenzamide

Nilotinib Impurity 58

CAT No: CL-NLT-77 CAS No: NA Mol Wt: 379.5 Mol F: C21H25N5O2 Inv Status: Custom Synthesis

Chemical Name: Ethyl 3-(3-((1E,2E)-3-(dimethylamino)-1-(pyridin-3-yl)allylidene)guanidino)-4-methylbenzoate

Nilotinib Impurity 59

CAT No: CL-NLT-78 CAS No: NA Mol Wt: 456.5 Mol F: C25H24N6O3 Inv Status: Custom Synthesis

Chemical Name: 3-(3-(3-((1E,2E)-3-amino-1-(pyridin-3-yl)allylidene)guanidino)-4-methylbenzamido)-4-methylbenzoic acid

Nilotinib Impurity 60

CAT No: CL-NLT-79 CAS No: NA Mol Wt: 375.4 Mol F: C20H21N7O Inv Status: Custom Synthesis

Chemical Name: N,N,3-trimethyl-4-(3-(4-(pyridin-3-yl)pyrimidin-2-yl)guanidino)benzamide

Nilotinib Impurity 61

CAT No: CL-NLT-80 CAS No: 2729981-89-7 Mol Wt: 322.3 Mol F: C17H14N4O3 Inv Status: Custom Synthesis

Chemical Name: 3-(2-((5-Carboxy-2-methylphenyl)amino)pyrimidin-4-yl)pyridine 1-oxide

Nilotinib Impurity 62

CAT No: CL-NLT-81 CAS No: NA Mol Wt: 321.3 Mol F: C17H15N5O2 Inv Status: Custom Synthesis

Chemical Name: 2-Amino-4-methyl-5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid

Type:Impurity Reference Standard

API NAME:Nilotinib

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