Impurity Reference Standard - Products

Regorafenib

CAT No: CL-RGFB-01 CAS No: 755037-03-7 Mol Wt: 482.8 Mol F: C21H15ClF4N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide

Regorafenib EP Impurity A

CAT No: CL-RGFB-02 CAS No: 757251-39-1 Mol Wt: 261.3 Mol F: C13H12FN3O2 Inv Status: Custom Synthesis

Chemical Name: 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

Regorafenib EP Impurity B

CAT No: CL-RGFB-03 CAS No: 2141961-84-2 Mol Wt: 303.3 Mol F: C15H14FN3O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-acetamido-3-fluorophenoxy)-N-methylpyridine-2-carboxamide

Regorafenib EP Impurity C

CAT No: CL-RGFB-04 CAS No: 1855006-12-0 Mol Wt: 395.4 Mol F: C20H18FN5O3 Inv Status: Custom Synthesis

Chemical Name: 4-[3-fluoro-4-[[2-(methylcarbamoyl)pyridin-4-yl]amino]phenoxy]-N-methylpyridine-2-carboxamide

Regorafenib EP Impurity D

CAT No: CL-RGFB-05 CAS No: 2438857-80-6 Mol Wt: 548.5 Mol F: C27H22F2N6O5 Inv Status: Custom Synthesis

Chemical Name: 4,4'-(((Carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide)

Regorafenib EP Impurity E

CAT No: CL-RGFB-06 CAS No: 2098799-13-2 Mol Wt: 811.5 Mol F: C35H23Cl2F7N6O5 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)phenoxy)-N-methylpicolinamide

Regorafenib FP Impurity A

CAT No: CL-RGFB-07 CAS No: 2514957-39-0 Mol Wt: 333.3 Mol F: C16H16FN3O4 Inv Status: Custom Synthesis

Chemical Name: Ethyl [2-fluoro-4-[[2-(methylcarbamoyl)pyridin-4-yl]oxy]phenyl]carbamate

Regorafenib desmethyl impurity

CAT No: CL-RGFB-08 CAS No: 1343498-72-5 Mol Wt: 468.8 Mol F: C20H13ClF4N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinamide

Regorafenib Dipyrimidine Impurity

CAT No: CL-RGFB-09 CAS No: NA Mol Wt: 380.4 Mol F: C20H17FN4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-((2-acetylpyridin-4-yl)amino)-3-fluorophenoxy)-N-methylpicolinamide

Regorafenib N-oxide

CAT No: CL-RGFB-10 CAS No: 835621-11-9 Mol Wt: 498.8 Mol F: C21H15ClF4N4O4 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(methylcarbamoyl)pyridine 1-oxide

N-Desmethyl Regorafenib N-Oxide

CAT No: CL-RGFB-11 CAS No: 835621-12-0 Mol Wt: 484.8 Mol F: C20H13ClF4N4O4 Inv Status: Custom Synthesis

Chemical Name: 2-Carbamoyl-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)pyridine 1-oxide

Regorafenib Urea Impurity

CAT No: CL-RGFB-12 CAS No: 1333390-56-9 Mol Wt: 348.7 Mol F: C14H9ClF4N2O2 Inv Status: Custom Synthesis

Chemical Name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea

Regorafenib Impurity 1

CAT No: CL-RGFB-14 CAS No: NA Mol Wt: 529.5 Mol F: C27H24FN7O4 Inv Status: Custom Synthesis

Chemical Name: 4,4'-((2-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)azanediyl)bis(N-methylpicolinamide)

Regorafenib Impurity 10

CAT No: CL-RGFB-15 CAS No: 2817629-88-0 Mol Wt: 276.3 Mol F: C14H13FN2O3 Inv Status: Custom Synthesis

Chemical Name: Ethyl 4-(4-amino-3-fluorophenoxy)picolinate

Regorafenib Impurity 11

CAT No: CL-RGFB-16 CAS No: 1020173-15-2 Mol Wt: 304.3 Mol F: C16H17FN2O3 Inv Status: Custom Synthesis

Chemical Name: Tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate

Regorafenib Impurity 12

CAT No: CL-RGFB-17 CAS No: 42265-69-0 Mol Wt: 209.6 Mol F: C8H7ClF3N Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-N-methyl-3-(trifluoromethyl)aniline

Regorafenib Impurity 14

CAT No: CL-RGFB-18 CAS No: NA Mol Wt: 570.2 Mol F: C22H12Cl2F7N3O3 Inv Status: Custom Synthesis

Chemical Name: 3-(4-Chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)-1-(2-fluoro-4-hydroxyphenyl)urea

Regorafenib Impurity 15

CAT No: CL-RGFB-19 CAS No: 2518416-73-2 Mol Wt: 570.2 Mol F: C22H12Cl2F7N3O3 Inv Status: Custom Synthesis

Chemical Name: 4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate

Regorafenib Impurity 16

CAT No: CL-RGFB-20 CAS No: NA Mol Wt: 638.7 Mol F: C23H11Cl3F9N3O2 Inv Status: Custom Synthesis

Chemical Name: 1,3-Bis(4-chloro-3-(trifluoromethyl)phenyl)-1-((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)urea

Regorafenib Impurity 17

CAT No: CL-RGFB-21 CAS No: NA Mol Wt: 348.7 Mol F: C14H9ClF4N2O2 Inv Status: Custom Synthesis

Chemical Name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-6-hydroxyphenyl)urea

Regorafenib Impurity 18

CAT No: CL-RGFB-22 CAS No: 2518234-85-8 Mol Wt: 491.5 Mol F: C25H19F2N5O4 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Amino-3-fluorophenoxy)-N-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)picolinamide

Regorafenib Impurity 2

CAT No: CL-RGFB-23 CAS No: 1209459-88-0 Mol Wt: 215.1 Mol F: C7H7BrN2O Inv Status: Custom Synthesis

Chemical Name: 4-Bromo-N-methylpicolinamide

Regorafenib Impurity 3

CAT No: CL-RGFB-24 CAS No: 611226-36-9 Mol Wt: 152.2 Mol F: C7H8N2O2 Inv Status: Custom Synthesis

Chemical Name: 4-Hydroxy-N-methylpicolinamide

Regorafenib Impurity 4

CAT No: CL-RGFB-25 CAS No: 1446410-29-2 Mol Wt: 199.6 Mol F: C8H10ClN3O Inv Status: Custom Synthesis

Chemical Name: 4-Chloro-N-methyl-6-(methylamino)picolinamide

Regorafenib Impurity 5

CAT No: CL-RGFB-26 CAS No: 2711-21-9 Mol Wt: 266.6 Mol F: C10H10ClF3N2O Inv Status: Custom Synthesis

Chemical Name: 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-ethylurea

Regorafenib Impurity 6

CAT No: CL-RGFB-27 CAS No: 2098799-12-1 Mol Wt: 368.4 Mol F: C19H17FN4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Amino-3-(4-amino-3-fluorophenoxy)phenoxy)-N-methylpicolinamide

Regorafenib Impurity 7

CAT No: CL-RGFB-28 CAS No: 2817629-89-1 Mol Wt: 248.2 Mol F: C12H9FN2O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Amino-3-fluorophenoxy)picolinic acid

Regorafenib Impurity 8

CAT No: CL-RGFB-29 CAS No: 757251-54-0 Mol Wt: 247.2 Mol F: C12H10FN3O2 Inv Status: Custom Synthesis

Chemical Name: 4-(4-Amino-3-fluorophenoxy)picolinamide

Regorafenib Impurity 9

CAT No: CL-RGFB-30 CAS No: 864245-61-4 Mol Wt: 262.2 Mol F: C13H11FN2O3 Inv Status: Custom Synthesis

Chemical Name: Methyl 4-(4-amino-3-fluorophenoxy)picolinate

Regorafenib Impurity II

CAT No: CL-RGFB-31 CAS No: NA Mol Wt: 317.3 Mol F: C16H16FN3O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(Ethylcarbamoyl)-3-fluorophenoxy)-N-methylpicolinamide

Regorafenib Impurity V

CAT No: CL-RGFB-32 CAS No: 2188236-16-8 Mol Wt: 448.4 Mol F: C21H16F4N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(3-fluoro-4-(3-(3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

1,3,5, Trimethoxy Benzene D9

CAT No: CL-RGFB-33 CAS No: 753456-99-4 Mol Wt: 177.2 Mol F: C9H3D9O3 Inv Status: Custom Synthesis

Chemical Name: 1,3,5-Tris(methoxy-d3)benzene

N-Desmethyl Regorafenib N-Oxide-D3

CAT No: CL-RGFB-34 CAS No: NA Mol Wt: 487.8 Mol F: C20H10D3ClF4N4O4 Inv Status: Custom Synthesis

Chemical Name: 2-Carbamoyl-4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)pyridine 1-oxide-3,5,6-d3

Regorafenib 13CD3

CAT No: CL-RGFB-35 CAS No: 2126178-55-8 Mol Wt: 486.8 Mol F: C2013CH12D3ClF4N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-(methyl-13C-d3)picolinamide

Regorafenib D3

CAT No: CL-RGFB-36 CAS No: 1255386-16-3 Mol Wt: 485.8 Mol F: C21H12D3ClF4N4O3 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-(methyl-d3)picolinamide

Regorafenib N-Oxide D3

CAT No: CL-RGFB-37 CAS No: 1333489-03-4 Mol Wt: 501.8 Mol F: C21H12D3ClF4N4O4 Inv Status: Custom Synthesis

Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-((methyl-d3)carbamoyl)pyridine 1-oxide

Type:Impurity Reference Standard

API NAME:Regorafenib

Total Products: 36

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