Impurity Reference Standard - Products

Tadalafil

CAT No: CL-TDF-01 CAS No: 171596-29-5 Mol Wt: 389.4 Mol F: C22H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]-pyrido[3,4-b]indole-1,4-dione

Tadalafil EP Impurity A

CAT No: CL-TDF-02 CAS No: 171596-27-3 Mol Wt: 389.4 Mol F: C22H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aS)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil EP Impurity B

CAT No: CL-TDF-03 CAS No: 629652-72-8 Mol Wt: 389.4 Mol F: C22H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6S,12aS)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil EP Impurity C

CAT No: CL-TDF-04 CAS No: NA Mol Wt: 389.4 : 36.5 : 3(18.0) Mol F: C22H19N3O4 : HCl : 3(H2O) Inv Status: Custom Synthesis

Chemical Name: (6S,12aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione hydrochloride trihydrate

Tadalafil EP Impurity D

CAT No: CL-TDF-05 CAS No: NA Mol Wt: 421.4 Mol F: C22H19N3O6 Inv Status: Custom Synthesis

Chemical Name: (6bR)-12-(1,3-Benzodioxol-5-yl)-12a-hydroxy-8-methyl- 6a,6b,8,9,12,12a-hexahydropyrazino[1',2':1,2]pyrrolo[3,4-c]quinoline-6,7,10(5H)-trione

Tadalafil EP Impurity E

CAT No: CL-TDF-06 CAS No: 1978322-99-4 Mol Wt: 421.4 Mol F: C22H19N3O6 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR,12bR)-6-(1,3-Benzodioxol-5-yl)-6a-hydroxy-2-methyl-2,3,6a,7,12a,12b-hexahydropyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4,12(6H)-trione

Tadalafil EP Impurity F

CAT No: CL-TDF-07 CAS No: 2747958-44-5 Mol Wt: 421.4 Mol F: C22H19N3O6 Inv Status: Custom Synthesis

Chemical Name: (8a'R)-6'-(1,3-Benzodioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-6'H-spiro[3,1-benzoxazine-4,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(1H)-trione

Tadalafil EP Impurity G

CAT No: CL-TDF-08 CAS No: 2520114-46-7 Mol Wt: 403 Mol F: C22H17N3O5 Inv Status: Custom Synthesis

Chemical Name: (12bR)-6-(1,3-Benzodioxol-5-yl)-12-hydroxy-2-methyl-2,3,6,12b-tetrahydropyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4-dione

Tadalafil EP Impurity H

CAT No: CL-TDF-09 CAS No: 1978322-98-3 Mol Wt: 421.5 Mol F: C22H19N3O6 Inv Status: Custom Synthesis

Chemical Name: (6R,14aR)-6-(1,3-Benzodioxol-5-yl)-2-methyl-2,3,14,14a-tetrahydropyrazino[1,2-d][1,4]benzodiazonine-1,4,7,13(6H,8H)-tetrone

Tadalafil EP Impurity I

CAT No: CL-TDF-10 CAS No: 2378614-29-8 Mol Wt: 405.4 Mol F: C22H19N3O5 : H2O Inv Status: Custom Synthesis

Chemical Name: (8a'R)-6'-(1,3-Benzodioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-6'H-spiro[indole-3,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(1H)-trione

Tadalafil N-Desmethyl N-Amino Impurity

CAT No: CL-TDF-11 CAS No: 1093940-69-2 Mol Wt: 390.3 Mol F: C21H18N4O4S Inv Status: Custom Synthesis

Chemical Name: (6S,12aS)-2-Amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil Intermediate 1

CAT No: CL-TDF-12 CAS No: 14907-27-8 Mol Wt: 218.3 : 36.5 Mol F: C12H14N2O2 : HCl Inv Status: Custom Synthesis

Chemical Name: Methyl D-tryptophanate hydrochloride

Tadalafil Impurity 1

CAT No: CL-TDF-13 CAS No: 171752-68-4 Mol Wt: 350.4:36.5 Mol F: C20H18N2O4 : HCl Inv Status: In Stock

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride

Tadalafil Chloroacetyl Impurity

CAT No: CL-TDF-14 CAS No: 171489-59-1 Mol Wt: 409 Mol F: C22H19ClN2O5 Inv Status: Custom Synthesis

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil EP Impurity A & C Mixture

CAT No: CL-TDF-15 CAS No: NA Mol Wt: 389.4 Mol F: C22H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aS)-6-(Benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione compound with (6S,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione (1:1)

Tadalafil Impurity 2

CAT No: CL-TDF-16 CAS No: 171596-43-3 Mol Wt: 350.4 Mol F: C20H18N2O4 Inv Status: Custom Synthesis

Chemical Name: Methyl (1S,3S)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Hydroxyl Lactam

CAT No: CL-TDF-17 CAS No: 951661-81-7 Mol Wt: 425.9 Mol F: C22H20ClN3O4 Inv Status: In Stock

Chemical Name: (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

Tadalafil Impurity 1 (free base)

CAT No: CL-TDF-18 CAS No: 171596-41-1 Mol Wt: 350.37 Mol F: C20H18N2O4 Inv Status: In Stock

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 16

CAT No: CL-TDF-19 CAS No: 951661-82-8 Mol Wt: 349.4 Mol F: C20H19N3O3 Inv Status: In Stock

Chemical Name: (1R,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

Tadalafil KSM Impurity 3

CAT No: CL-TDF-20 CAS No: 171596-42-2 Mol Wt: 350.37 Mol F: C20H18N2O4 Inv Status: In Stock

Chemical Name: (1S,3R)-Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate

(1R, 3S) Open Ring Tadalafil Impurity

CAT No: CL-TDF-21 CAS No: 629652-44-4 Mol Wt: 426.85 Mol F: C22H19ClN2O5 Inv Status: In Stock

Chemical Name: (1R,3S)-1-Benzo[1,3]dioxol-5-yl-2-(2-chloro-acetyl)-2,3,4,9-tetrahydro-1H-b-carboline-3-carboxylic acid methyl ester

Tadalafil Impurity 5

CAT No: CL-TDF-22 CAS No: 629652-40-0 Mol Wt: NA Mol F: NA Inv Status: Custom Synthesis

Chemical Name: (1S,3R)-1-(1,3-Benzodioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro1H-pyrido[3,4-b]indole-3-carboxylic Acid Methyl Ester

Tadalafil Impurity 9

CAT No: CL-TDF-23 CAS No: 7797-83-3 Mol Wt: 150.1 Mol F: C8H6O3 Inv Status: Custom Synthesis

Chemical Name: Benzo[d][1,3]dioxole-4-carbaldehyde

Tadalafil Impurity 10

CAT No: CL-TDF-24 CAS No: 495-76-1 Mol Wt: 152.1 Mol F: C8H8O3 Inv Status: Custom Synthesis

Chemical Name: Benzo[d][1,3]dioxol-5-ylmethanol

Tadalafil Impurity 11

CAT No: CL-TDF-25 CAS No: 769-30-2 Mol Wt: 152.1 Mol F: C8H8O3 Inv Status: Custom Synthesis

Chemical Name: Benzo[d][1,3]dioxol-4-ylmethanol

Tadalafil Impurity 12

CAT No: CL-TDF-26 CAS No: 326-61-4 Mol Wt: 194.2 Mol F: C10H10O4 Inv Status: Custom Synthesis

Chemical Name: Benzo[d][1,3]dioxol-5-ylmethyl acetate

Tadalafil Impurity 13

CAT No: CL-TDF-27 CAS No: NA Mol Wt: 503.3 Mol F: C24H20Cl2N2O6 Inv Status: Custom Synthesis

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-4-yl)-2,9-bis(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 14

CAT No: CL-TDF-28 CAS No: NA Mol Wt: 407.4 Mol F: C22H21N3O5 Inv Status: Custom Synthesis

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-4-yl)-2-glycyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 15

CAT No: CL-TDF-29 CAS No: 23434-88-0 Mol Wt: 289.4 Mol F: C17H23NO3 Inv Status: Custom Synthesis

Chemical Name: 5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)pentan-1-one

Tadalafil Impurity 17

CAT No: CL-TDF-31 CAS No: 951661-84-0 Mol Wt: 425.9 Mol F: C22H20ClN3O4 Inv Status: Custom Synthesis

Chemical Name: (1S,3R)-1-(Benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

Tadalafil Impurity 18

CAT No: CL-TDF-32 CAS No: 2169996-11-4 Mol Wt: 435.5 Mol F: C24H25N3O5 Inv Status: Custom Synthesis

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(dimethylglycyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Nor-Tadalafil

CAT No: CL-TDF-33 CAS No: 171596-36-4 Mol Wt: 375.4 Mol F: C21H17N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Desmethylene Tadalafil

CAT No: CL-TDF-34 CAS No: 171489-03-5 Mol Wt: 377.4 Mol F: C21H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(3,4-dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

(1S, 3S) Open Ring Tadalafil Impurity

CAT No: CL-TDF-35 CAS No: 629652-42-2 Mol Wt: 426.9 Mol F: C22H19ClN2O5 Inv Status: Custom Synthesis

Chemical Name: Methyl (1S,3S)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Acid Impurity

CAT No: CL-TDF-36 CAS No: 474668-76-3 Mol Wt: 336.3 : 36.5 Mol F: C19H16N2O4 : HCl Inv Status: Custom Synthesis

Chemical Name: 1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid hydrochloride

Tadalafil Impurity 19

CAT No: CL-TDF-37 CAS No: 2058231-08-4 Mol Wt: 412.8 Mol F: C21H17ClN2O5 Inv Status: Custom Synthesis

Chemical Name: (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Tadalafil EP Impurity I (Hydrate)

CAT No: CL-TDF-38 CAS No: NA Mol Wt: 405.4 : 18.0 Mol F: C22H19N3O5 : H2O Inv Status: Custom Synthesis

Chemical Name: (8a?R)-6?-(1,3-benzodioxol-5-yl)-2?-methyl-2?,3?,8?,8a?-tetrahydro-6?H-spiro[indole-3,7?-pyrrolo[1,2-a]pyrazine]-1?,2,4?(1H)-trione hydrate

Tadalafil Impurity 20

CAT No: CL-TDF-40 CAS No: 59259-90-4 Mol Wt: 196.2 Mol F: C10H12O4 Inv Status: Custom Synthesis

Chemical Name: 5-(Dimethoxymethyl)benzo[d][1,3]dioxole

Tadalafil N-Oxide

CAT No: CL-TDF-41 CAS No: NA Mol Wt: 404.4 Mol F: C22H18N3O5 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-1,4-dioxo-1,3,4,6,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-7(2H)-olate

Tafamidis Meglumine

CAT No: CL-TDF-42 CAS No: 951395-08-7 Mol Wt: 308.1 : 195.2 Mol F: C14H7Cl2NO3 : C7H17NO5 Inv Status: Custom Synthesis

Chemical Name: 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic Acid (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol

Tafamidis Impurity 1

CAT No: CL-TDF-43 CAS No: 619-14-7 Mol Wt: 183.1 Mol F: C7H5NO5 Inv Status: Custom Synthesis

Chemical Name: 3-Hydroxy-4-nitrobenzoic acid

Tafamidis Impurity 2

CAT No: CL-TDF-44 CAS No: 2789-92-6 Mol Wt: 206 Mol F: C7H5Cl2NO2 Inv Status: Custom Synthesis

Chemical Name: 2-Amino-3,5-dichlorobenzoic acid

Tafamidis Impurity 3

CAT No: CL-TDF-45 CAS No: 1184581-58-5 Mol Wt: 326.1 Mol F: C14H9Cl2NO4 Inv Status: Custom Synthesis

Chemical Name: 4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid

Tafamidis Impurity 4

CAT No: CL-TDF-46 CAS No: 1507158-86-2 Mol Wt: 308.1 Mol F: C14H7Cl2NO3 Inv Status: Custom Synthesis

Chemical Name: 2-(3,4-dichlorphenyl)-6-benzoxazolecarboxylic acid

Tafamidis Impurity 5

CAT No: CL-TDF-47 CAS No: 1521571-08-3 Mol Wt: 372.7 Mol F: C14H8ClNO3 Inv Status: Custom Synthesis

Chemical Name: 2-(3-chlorophenyl)-6-benzoxazolecarboxylic acid

Tafamidis Impurity 6

CAT No: CL-TDF-48 CAS No: 1395964-06-3 Mol Wt: 322.1 Mol F: C15H9Cl2NO3 Inv Status: Custom Synthesis

Chemical Name: 2-(3,5-dichlorphenyl)-6-benzoxazolecarboxylic acid methyl ester

Tafamidis Impurity 7

CAT No: CL-TDF-49 CAS No: 1179721-81-3 Mol Wt: 291.7 Mol F: C14H10ClNO4 Inv Status: Custom Synthesis

Chemical Name: 4-(3-Chlorobenzamido)-3-hydroxybenzoic acid

Tafamidis Impurity 9

CAT No: CL-TDF-50 CAS No: 2905-67-1 Mol Wt: 205 Mol F: C8H6Cl2O2 Inv Status: Custom Synthesis

Chemical Name: Methyl 3,5-dichlorobenzoate

Tafamidis Impurity 10

CAT No: CL-TDF-51 CAS No: 1018498-30-0 Mol Wt: 273.7 Mol F: C14H8ClNO3 Inv Status: Custom Synthesis

Chemical Name: 2-(2-Chlorophenyl)benzo[d]oxazole-5-carboxylic acid

Tafamidis Acyl Glucuronide

CAT No: CL-TDF-52 CAS No: NA Mol Wt: 484.2 Mol F: C20H15Cl2NO9 Inv Status: Custom Synthesis

Chemical Name: (2S,3S,4S,5R,6S)-6-((2-(3,5-Dichlorophenyl)benzo[d]oxazole-6-carbonyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

Tadalafil Impurity 21

CAT No: CL-TDF-53 CAS No: 2058231-08-4 Mol Wt: 412.8 Mol F: C21H17ClN2O5 Inv Status: Custom Synthesis

Chemical Name: (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid

Tadalafil Impurity 22

CAT No: CL-TDF-54 CAS No: 27738-46-1 Mol Wt: 196.2 Mol F: C9H8O5 Inv Status: Custom Synthesis

Chemical Name: 2-(Benzo[d][1,3]dioxol-5-yl)-2-hydroxyacetic acid

Tadalafil Impurity 23

CAT No: CL-TDF-55 CAS No: 321862-32-2 Mol Wt: 346.3 Mol F: C20H14N2O4 Inv Status: Custom Synthesis

Chemical Name: Methyl 1-(benzo[d][1,3]dioxol-5-yl)-9H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 24

CAT No: CL-TDF-56 CAS No: NA Mol Wt: 364.4 Mol F: C21H20N2O4 Inv Status: Custom Synthesis

Chemical Name: Methyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 25

CAT No: CL-TDF-57 CAS No: NA Mol Wt: 368.8 Mol F: C20H17ClN2O3 Inv Status: Custom Synthesis

Chemical Name: (S)-1-(1-(benzo[d][1,3]dioxol-5-yl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-2-chloroethan-1-one

Tadalafil Impurity 26

CAT No: CL-TDF-58 CAS No: 1158945-78-8 Mol Wt: 364.4 Mol F: C21H20N2O4 Inv Status: Custom Synthesis

Chemical Name: Ethyl (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate

Tadalafil Impurity 3

CAT No: CL-TDF-59 CAS No: 2520114-84-3 Mol Wt: 377.4 Mol F: C21H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6S,12aS)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil Impurity 4

CAT No: CL-TDF-60 CAS No: NA Mol Wt: 377.4 Mol F: C21H19N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aS)-6-(3,4-Dihydroxyphenyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil Impurity 6

CAT No: CL-TDF-61 CAS No: 20850-43-5 Mol Wt: 170.6 Mol F: C8H7ClO2 Inv Status: Custom Synthesis

Chemical Name: 5-(Chloromethyl)benzo[d][1,3]dioxole

Tadalafil Impurity 7

CAT No: CL-TDF-62 CAS No: 749864-17-3 Mol Wt: 350.4 Mol F: C20H18N2O4 Inv Status: Custom Synthesis

Chemical Name: Methyl (R,E)-2-((benzo[d][1,3]dioxol-5-ylmethylene)amino)-3-(1H-indol-3-yl)propanoate

Tadalafil Impurity 8

CAT No: CL-TDF-63 CAS No: 2520114-95-6 Mol Wt: 465.9 Mol F: C24H20ClN3O5 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-7-(2-chloroacetyl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Tadalafil D3

CAT No: CL-TDF-64 CAS No: 960226-55-5 Mol Wt: 392.4 Mol F: C22H16D3N3O4 Inv Status: Custom Synthesis

Chemical Name: (6R,12aR)-6-(Benzo[d][1,3]dioxol-5-yl)-2-(methyl-d3)-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione

Type:Impurity Reference Standard

API NAME:Tadalafil

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